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Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp M-207 Associated with the Deep-Sea Coral Lophelia pertusa

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dc.contributor.authorBrana, Alfredo F.
dc.contributor.authorSarmiento-Vizcaino, Aida
dc.contributor.authorOsset, Miguel
dc.contributor.authorPerez-Victoria, Ignacio
dc.contributor.authorMartin, Jesus
dc.contributor.authorde Pedro, Nuria
dc.contributor.authorde la Cruz, Mercedes
dc.contributor.authorDiaz, Caridad
dc.contributor.authorVicente, Francisca
dc.contributor.authorReyes, Fernando
dc.contributor.authorGarcia, Luis A.
dc.contributor.authorBlanco, Gloria
dc.contributor.authoraffiliation[Brana, Alfredo F.] Univ Oviedo, Inst Univ Oncol Principado Asturias, Area Microbiol, Dept Biol, E-33006 Oviedo, Spain
dc.contributor.authoraffiliation[Sarmiento-Vizcaino, Aida] Univ Oviedo, Inst Univ Oncol Principado Asturias, Area Microbiol, Dept Biol, E-33006 Oviedo, Spain
dc.contributor.authoraffiliation[Osset, Miguel] Univ Oviedo, Inst Univ Oncol Principado Asturias, Area Microbiol, Dept Biol, E-33006 Oviedo, Spain
dc.contributor.authoraffiliation[Blanco, Gloria] Univ Oviedo, Inst Univ Oncol Principado Asturias, Area Microbiol, Dept Biol, E-33006 Oviedo, Spain
dc.contributor.authoraffiliation[Perez-Victoria, Ignacio] Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain
dc.contributor.authoraffiliation[Martin, Jesus] Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain
dc.contributor.authoraffiliation[de Pedro, Nuria] Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain
dc.contributor.authoraffiliation[de la Cruz, Mercedes] Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain
dc.contributor.authoraffiliation[Diaz, Caridad] Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain
dc.contributor.authoraffiliation[Vicente, Francisca] Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain
dc.contributor.authoraffiliation[Reyes, Fernando] Ctr Excelencia Invest Med Innovadores Andalucia, Fdn MEDINA, Avda Conocimiento 3,Parque Tecnol Ciencias Salud, E-18016 Granada, Spain
dc.contributor.authoraffiliation[Garcia, Luis A.] Univ Oviedo, Area Ingn Quim, Dept Ingn Quim & Tecnol Medio Ambiente, Oviedo 33006, Spain
dc.contributor.funderUniversidad de Oviedo
dc.contributor.funderGobierno del Principado de Asturias
dc.contributor.funderMinisterio de Ciencia e Innovacion
dc.date.accessioned2023-02-12T02:23:05Z
dc.date.available2023-02-12T02:23:05Z
dc.date.issued2017-05-01
dc.description.abstractThe present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Aviles Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.
dc.identifier.doi10.3390/md15050144
dc.identifier.essn1660-3397
dc.identifier.unpaywallURLhttps://www.mdpi.com/1660-3397/15/5/144/pdf
dc.identifier.urihttp://hdl.handle.net/10668/19298
dc.identifier.wosID404235100020
dc.issue.number5
dc.journal.titleMarine drugs
dc.journal.titleabbreviationMar. drugs
dc.language.isoen
dc.organizationFundación MEDINA (Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía)
dc.organizationFundación MEDINA
dc.publisherMdpi
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectlobophorins
dc.subjectspirotetronate antibiotic
dc.subjectStreptomyces
dc.subjectantitumor
dc.subjectCantabrian Sea-derived actinobacteria
dc.subjectSpirotetronate antibiotics
dc.subjectMetabolites
dc.titleLobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp M-207 Associated with the Deep-Sea Coral Lophelia pertusa
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number15
dc.wostypeArticle
dspace.entity.typePublication

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