Publication:
Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people.

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Date

2022-09-08

Authors

Vitallé, Joana
Pérez-Gómez, Alberto
Ostos, Francisco José
Gasca-Capote, Carmen
Jiménez-León, María Reyes
Bachiller, Sara
Rivas-Jeremías, Inmaculada
Silva-Sánchez, Maria Del Mar
Ruiz-Mateos, Anabel M
Martín-Sánchez, María Ángeles

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Abstract

The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2-specific T cell response. The dramatic decrease in thymic function in people > 60 years, which fueled alteration in T cell homeostasis, and their lower CD161+ T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the > 60-year-old group, which was also related to lower specific T cell response after vaccination. These findings might be relevant for the improvement of the current vaccination strategies and for the development of new vaccine prototypes.

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MeSH Terms

Aged
BNT162 Vaccine
COVID-19
COVID-19 Vaccines
Humans
Middle Aged
SARS-CoV-2
Vaccines, Synthetic
Viral Vaccines
mRNA Vaccines

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Keywords

Adaptive immunity, Cellular senescence, Immunology, Innate immunity, Vaccines

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