Publication: Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people.
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Identifiers
Date
2022-09-08
Authors
Vitallé, Joana
Pérez-Gómez, Alberto
Ostos, Francisco José
Gasca-Capote, Carmen
Jiménez-León, María Reyes
Bachiller, Sara
Rivas-Jeremías, Inmaculada
Silva-Sánchez, Maria Del Mar
Ruiz-Mateos, Anabel M
Martín-Sánchez, María Ángeles
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Journal Title
Journal ISSN
Volume Title
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Abstract
The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2-specific T cell response. The dramatic decrease in thymic function in people > 60 years, which fueled alteration in T cell homeostasis, and their lower CD161+ T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the > 60-year-old group, which was also related to lower specific T cell response after vaccination. These findings might be relevant for the improvement of the current vaccination strategies and for the development of new vaccine prototypes.
Description
MeSH Terms
Aged
BNT162 Vaccine
COVID-19
COVID-19 Vaccines
Humans
Middle Aged
SARS-CoV-2
Vaccines, Synthetic
Viral Vaccines
mRNA Vaccines
BNT162 Vaccine
COVID-19
COVID-19 Vaccines
Humans
Middle Aged
SARS-CoV-2
Vaccines, Synthetic
Viral Vaccines
mRNA Vaccines
DeCS Terms
CIE Terms
Keywords
Adaptive immunity, Cellular senescence, Immunology, Innate immunity, Vaccines