%0 Journal Article
%A Vitallé, Joana
%A Pérez-Gómez, Alberto
%A Ostos, Francisco José
%A Gasca-Capote, Carmen
%A Jiménez-León, María Reyes
%A Bachiller, Sara
%A Rivas-Jeremías, Inmaculada
%A Silva-Sánchez, Maria Del Mar
%A Ruiz-Mateos, Anabel M
%A Martín-Sánchez, María Ángeles
%A López-Cortes, Luis Fernando
%A Rafii-El-Idrissi Benhnia, Mohammed
%A Ruiz-Mateos, Ezequiel
%T Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people.
%D 2022
%U http://hdl.handle.net/10668/20206
%X The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2-specific T cell response. The dramatic decrease in thymic function in people > 60 years, which fueled alteration in T cell homeostasis, and their lower CD161+ T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the > 60-year-old group, which was also related to lower specific T cell response after vaccination. These findings might be relevant for the improvement of the current vaccination strategies and for the development of new vaccine prototypes.
%K Adaptive immunity
%K Cellular senescence
%K Immunology
%K Innate immunity
%K Vaccines
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