RT Journal Article
T1 Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people.
A1 Vitallé, Joana
A1 Pérez-Gómez, Alberto
A1 Ostos, Francisco José
A1 Gasca-Capote, Carmen
A1 Jiménez-León, María Reyes
A1 Bachiller, Sara
A1 Rivas-Jeremías, Inmaculada
A1 Silva-Sánchez, Maria Del Mar
A1 Ruiz-Mateos, Anabel M
A1 Martín-Sánchez, María Ángeles
A1 López-Cortes, Luis Fernando
A1 Rafii-El-Idrissi Benhnia, Mohammed
A1 Ruiz-Mateos, Ezequiel
K1 Adaptive immunity
K1 Cellular senescence
K1 Immunology
K1 Innate immunity
K1 Vaccines
AB The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2-specific T cell response. The dramatic decrease in thymic function in people > 60 years, which fueled alteration in T cell homeostasis, and their lower CD161+ T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the > 60-year-old group, which was also related to lower specific T cell response after vaccination. These findings might be relevant for the improvement of the current vaccination strategies and for the development of new vaccine prototypes.
YR 2022
FD 2022-09-08
LK http://hdl.handle.net/10668/20206
UL http://hdl.handle.net/10668/20206
LA en
DS RISalud
RD Apr 5, 2025