Publication:
Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people.

dc.contributor.authorVitalle, Joana
dc.contributor.authorPerez-Gomez, Alberto
dc.contributor.authorOstos, Francisco Jose
dc.contributor.authorGasca-Capote, Carmen
dc.contributor.authorJimenez-Leon, Maria Reyes
dc.contributor.authorBachiller, Sara
dc.contributor.authorRivas-Jeremias, Inmaculada
dc.contributor.authorSilva-Sanchez, Maria Del Mar
dc.contributor.authorRuiz-Mateos, Anabel M
dc.contributor.authorMartin-Sanchez, Maria Angeles
dc.contributor.authorLopez-Cortes, Luis Fernando
dc.contributor.authorRafii-El-Idrissi Benhnia, Mohammed
dc.contributor.authorRuiz-Mateos, Ezequiel
dc.contributor.funderConsejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de Andalucía
dc.contributor.funderConsejería de Salud, Junta de Andalucía
dc.date.accessioned2023-05-03T13:32:13Z
dc.date.available2023-05-03T13:32:13Z
dc.date.issued2022-09-08
dc.description.abstractThe immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2-specific T cell response. The dramatic decrease in thymic function in people > 60 years, which fueled alteration in T cell homeostasis, and their lower CD161+ T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the > 60-year-old group, which was also related to lower specific T cell response after vaccination. These findings might be relevant for the improvement of the current vaccination strategies and for the development of new vaccine prototypes.
dc.description.sponsorshipThis work was supported by the Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de Andalucía grants CV20-85418 and P20_00906 and by research contracts DOC-01659 and DOC-00963, as well as by Consejería de Salud, Junta de Andalucía research contract RH-0037-2020 and Instituto de Salud Carlos III CP19/00159, FI17/00186, FI19/00083, PI19/01127, and CM20/00243 from Fondos FEDER. ERM was supported by the Spanish Research Council (CSIC). We thank all the community volunteers, participants from the IBiS, Chema Niño, and the nursing staff from Virgen del Rocío University Hospital who have taken part in this project. We also thank Alicia Gutierrez and Esperanza Muñoz for reviewing the manuscript. In memoriam Silvio Manuel Pérez Martín.
dc.description.versionSi
dc.identifier.citationVitallé J, Pérez-Gómez A, Ostos FJ, Gasca-Capote C, Jiménez-León MR, Bachiller S, et al. Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people. JCI Insight. 2022 Sep 8;7(17):e161045.
dc.identifier.doi10.1172/jci.insight.161045
dc.identifier.essn2379-3708
dc.identifier.pmcPMC9536264
dc.identifier.pmid35943812
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536264/pdf
dc.identifier.unpaywallURLhttp://insight.jci.org/articles/view/161045/files/pdf
dc.identifier.urihttp://hdl.handle.net/10668/20206
dc.issue.number17
dc.journal.titleJCI insight
dc.journal.titleabbreviationJCI Insight
dc.language.isoen
dc.organizationHospital Universitario Virgen del Rocío
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationCentro de Salud Pinillo Chico
dc.provenanceRealizada la curación de contenido 30/05/2025.
dc.publisherAmerican Society for Clinical Investigation
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.projectIDCV20-85418
dc.relation.projectIDP20_00906
dc.relation.projectIDDOC-01659
dc.relation.projectIDDOC-00963
dc.relation.projectIDRH-0037-2020
dc.relation.publisherversionhttps://doi.org/10.1172/jci.insight.161045
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAdaptive immunity
dc.subjectCellular senescence
dc.subjectImmunology
dc.subjectInnate immunity
dc.subjectVaccines
dc.subject.decsSARS-CoV-2
dc.subject.decsVacunación
dc.subject.decsDosificación
dc.subject.decsVacuna BNT162
dc.subject.decsFactores inmunológicos
dc.subject.decsEnvejecimiento
dc.subject.decsHomeostasis
dc.subject.meshAged
dc.subject.meshBNT162 Vaccine
dc.subject.meshCOVID-19
dc.subject.meshCOVID-19 Vaccines
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshSARS-CoV-2
dc.subject.meshVaccines, Synthetic
dc.subject.meshViral Vaccines
dc.subject.meshmRNA Vaccines
dc.titleImmune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number7
dspace.entity.typePublication

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