Publication: Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development
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2017-01-01
Authors
Casas, Rosa
Urpi-Sarda, Mireia
Sacanella, Emilio
Arranz, Sara
Corella, Dolores
Castaner, Olga
Lamuela-Raventos, Rosa-Maria
Salas-Salvado, Jordi
Lapetra, Jose
Portillo, Maria P.
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Hindawi ltd
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Abstract
Objective. To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex (R). Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1 beta (P
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Low-grade inflammation, Cardiovascular-disease, High-risk, Markers, Atherosclerosis, Activation, Cytokines, Pattern