%0 Journal Article
%A Casas, Rosa
%A Urpi-Sarda, Mireia
%A Sacanella, Emilio
%A Arranz, Sara
%A Corella, Dolores
%A Castaner, Olga
%A Lamuela-Raventos, Rosa-Maria
%A Salas-Salvado, Jordi
%A Lapetra, Jose
%A Portillo, Maria P.
%A Estruch, Ramon
%T Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development
%D 2017
%@ 0962-9351
%U http://hdl.handle.net/10668/19055
%X Objective. To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex (R). Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1 beta (P
%K Low-grade inflammation
%K Cardiovascular-disease
%K High-risk
%K Markers
%K Atherosclerosis
%K Activation
%K Cytokines
%K Pattern
%~