Publication:
Transcription-mediated replication hindrance: a major driver of genome instability.

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Date

2019-05-23

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Gómez-González, Belén
Aguilera, Andrés

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Abstract

Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA structures such as R loops. Experimental evidence reveals that an engaged transcription machinery at the DNA can either enhance such obstacles or be an obstacle itself. Thus, transcription can become a potentially hazardous process promoting localized replication fork hindrance and stress, which would ultimately cause genome instability, a hallmark of cancer cells. Understanding the causes behind transcription-replication conflicts as well as how the cell resolves them to sustain genome integrity is the aim of this review.

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DNA Replication
Genome
Genomic Instability
Humans
Neoplasms
Transcription Elongation, Genetic
Transcription, Genetic

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DNA–RNA hybrids, chromosome fragility, genetic instability, replication fork stalling, transcription

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