Publication: Transcription-mediated replication hindrance: a major driver of genome instability.
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Date
2019-05-23
Authors
Gómez-González, Belén
Aguilera, Andrés
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Abstract
Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA structures such as R loops. Experimental evidence reveals that an engaged transcription machinery at the DNA can either enhance such obstacles or be an obstacle itself. Thus, transcription can become a potentially hazardous process promoting localized replication fork hindrance and stress, which would ultimately cause genome instability, a hallmark of cancer cells. Understanding the causes behind transcription-replication conflicts as well as how the cell resolves them to sustain genome integrity is the aim of this review.
Description
MeSH Terms
DNA Replication
Genome
Genomic Instability
Humans
Neoplasms
Transcription Elongation, Genetic
Transcription, Genetic
Genome
Genomic Instability
Humans
Neoplasms
Transcription Elongation, Genetic
Transcription, Genetic
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Keywords
DNA–RNA hybrids, chromosome fragility, genetic instability, replication fork stalling, transcription