%0 Journal Article
%A Gómez-González, Belén
%A Aguilera, Andrés
%T Transcription-mediated replication hindrance: a major driver of genome instability.
%D 2019
%U http://hdl.handle.net/10668/14011
%X Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA structures such as R loops. Experimental evidence reveals that an engaged transcription machinery at the DNA can either enhance such obstacles or be an obstacle itself. Thus, transcription can become a potentially hazardous process promoting localized replication fork hindrance and stress, which would ultimately cause genome instability, a hallmark of cancer cells. Understanding the causes behind transcription-replication conflicts as well as how the cell resolves them to sustain genome integrity is the aim of this review.
%K DNA–RNA hybrids
%K chromosome fragility
%K genetic instability
%K replication fork stalling
%K transcription
%~