TY - JOUR AU - Gómez-González, Belén AU - Aguilera, Andrés PY - 2019 DO - 10.1101/gad.324517.119 UR - http://hdl.handle.net/10668/14011 T2 - Genes & development AB - Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA structures such as R loops. Experimental evidence reveals that an engaged... LA - en KW - DNA–RNA hybrids KW - chromosome fragility KW - genetic instability KW - replication fork stalling KW - transcription KW - DNA Replication KW - Genome KW - Genomic Instability KW - Humans KW - Neoplasms KW - Transcription Elongation, Genetic KW - Transcription, Genetic TI - Transcription-mediated replication hindrance: a major driver of genome instability. TY - research article VL - 33 ER -