RT Journal Article
T1 Transcription-mediated replication hindrance: a major driver of genome instability.
A1 Gómez-González, Belén
A1 Aguilera, Andrés
K1 DNA–RNA hybrids
K1 chromosome fragility
K1 genetic instability
K1 replication fork stalling
K1 transcription
AB Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA structures such as R loops. Experimental evidence reveals that an engaged transcription machinery at the DNA can either enhance such obstacles or be an obstacle itself. Thus, transcription can become a potentially hazardous process promoting localized replication fork hindrance and stress, which would ultimately cause genome instability, a hallmark of cancer cells. Understanding the causes behind transcription-replication conflicts as well as how the cell resolves them to sustain genome integrity is the aim of this review.
YR 2019
FD 2019-05-23
LK http://hdl.handle.net/10668/14011
UL http://hdl.handle.net/10668/14011
LA en
DS RISalud
RD Apr 10, 2025