Publication: Melatonin-doped polymeric nanoparticles induce high crystalline apatite formation in root dentin
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Date
2021-11-03
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Toledano-Osorio, Manuel
Aguilera, Fatima S.
Munoz-Soto, Esther
Osorio, Estrella
Toledano, Manuel
Escames, Germaine
Medina-Castillo, Antonio L.
Osorio, Maria T.
Lopez-Lopez, Modesto T.
Vallecillo-Rivas, Marta
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Elsevier sci ltd
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Abstract
Objective. To investigate the effect of novel polymeric nanoparticles (NPs) doped with melatonin (ML) on nano-hardness, crystallinity and ultrastructure of the formed hydroxyapatite after endodontic treatment. Methods. Undoped-NPs and ML-doped NPs (ML-NPs) were tested at radicular dentin, after 24 h and 6 m. A control group without NPs was included. Radicular cervical and apical dentin surfaces were studied by nano-hardness measurements, X-ray diffraction and transmission electron microscopy. Mean and standard deviation were analyzed by ANOVA and StudentNewman-Keuls multiple comparisons (p
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Apatite, Dentin, Hardness, Melatonin, Polymeric nanoparticles, Remineralization, Transmission electron microscopy, X-ray diffraction, Oxidative stress, Carious dentin, Organic matrix, Hydroxyapatite, Bone, Cements, Remineralization, Mineralization, Interface, Texture