Publication: A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics.
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Date
2015-04-14
Authors
Cornejo-Garcia, J A
Romano, A
Gueant-Rodriguez, R M
Oussalah, A
Blanca-Lopez, N
Gaeta, F
Tramoy, D
Josse, T
Doña, I
Torres, M J
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Publisher
Nature Publishing Group
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Abstract
Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (PHis substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcɛRI pathway in this pathology.
Description
MeSH Terms
Adult
Anti-Bacterial Agents
Case-Control Studies
Drug Hypersensitivity
Exons
Female
Galectin 3
Galectins
Humans
Hypersensitivity, Immediate
Immunoglobulin E
Italy
Male
Middle Aged
Anti-Bacterial Agents
Case-Control Studies
Drug Hypersensitivity
Exons
Female
Galectin 3
Galectins
Humans
Hypersensitivity, Immediate
Immunoglobulin E
Italy
Male
Middle Aged
DeCS Terms
Inmunoglobulina E
Hipersensibilidad
Galectina 3
Galactosa
Lectinas
Hipersensibilidad
Galectina 3
Galactosa
Lectinas
CIE Terms
Keywords
Polymorphism, Single Nucleotide, Protein Structure, Tertiary, Spain, beta-Lactams, Blood Proteins
Citation
Cornejo-García JA, Romano A, Guéant-Rodríguez RM, Oussalah A, Blanca-López N, Gaeta F, et al. A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics. Pharmacogenomics J. 2016 Feb;16(1):79-82