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A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics.

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dc.contributor.authorCornejo-Garcia, J A
dc.contributor.authorRomano, A
dc.contributor.authorGueant-Rodriguez, R M
dc.contributor.authorOussalah, A
dc.contributor.authorBlanca-Lopez, N
dc.contributor.authorGaeta, F
dc.contributor.authorTramoy, D
dc.contributor.authorJosse, T
dc.contributor.authorDoña, I
dc.contributor.authorTorres, M J
dc.contributor.authorCanto, G
dc.contributor.authorBlanca, M
dc.contributor.authorGueant, J-L
dc.contributor.funderInserm
dc.contributor.funderLorraine Region
dc.contributor.funderSpanish Ministry Fund for Health in Spain
dc.date.accessioned2023-01-25T08:30:39Z
dc.date.available2023-01-25T08:30:39Z
dc.date.issued2015-04-14
dc.description.abstractGenetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (PHis substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcɛRI pathway in this pathology.
dc.description.sponsorshipManuscript was supported in part by Grants from Inserm, the Lorraine Region and PHRC (Hospital clinical research program, 2012, PHRC 189), and from Spanish Ministry Fund for Health in Spain (FIS) network RIRAAF (RD12/0013), and PS09/02419.
dc.description.versionSi
dc.identifier.citationCornejo-García JA, Romano A, Guéant-Rodríguez RM, Oussalah A, Blanca-López N, Gaeta F, et al. A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics. Pharmacogenomics J. 2016 Feb;16(1):79-82
dc.identifier.doi10.1038/tpj.2015.24
dc.identifier.essn1473-1150
dc.identifier.pmid25869013
dc.identifier.urihttp://hdl.handle.net/10668/9750
dc.issue.number1
dc.journal.titleThe pharmacogenomics journal
dc.journal.titleabbreviationPharmacogenomics J
dc.language.isoen
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.organizationHospital Universitario Regional de Málaga
dc.page.number79-82
dc.provenanceRealizada la curación de contenido 05/03/2025
dc.publisherNature Publishing Group
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.projectIDRD12/0013
dc.relation.projectIDPS09/02419
dc.relation.publisherversionhttps://doi.org/10.1038/tpj.2015.24
dc.rights.accessRightsRestricted access
dc.subjectPolymorphism, Single Nucleotide
dc.subjectProtein Structure, Tertiary
dc.subjectSpain
dc.subjectbeta-Lactams
dc.subjectBlood Proteins
dc.subject.decsInmunoglobulina E
dc.subject.decsHipersensibilidad
dc.subject.decsGalectina 3
dc.subject.decsGalactosa
dc.subject.decsLectinas
dc.subject.meshAdult
dc.subject.meshAnti-Bacterial Agents
dc.subject.meshCase-Control Studies
dc.subject.meshDrug Hypersensitivity
dc.subject.meshExons
dc.subject.meshFemale
dc.subject.meshGalectin 3
dc.subject.meshGalectins
dc.subject.meshHumans
dc.subject.meshHypersensitivity, Immediate
dc.subject.meshImmunoglobulin E
dc.subject.meshItaly
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.titleA non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics.
dc.typeresearch article
dc.volume.number16
dspace.entity.typePublication

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