%0 Journal Article
%A Cornejo-Garcia, J A
%A Romano, A
%A Gueant-Rodriguez, R M
%A Oussalah, A
%A Blanca-Lopez, N
%A Gaeta, F
%A Tramoy, D
%A Josse, T
%A Doña, I
%A Torres, M J
%A Canto, G
%A Blanca, M
%A Gueant, J-L
%T A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics.
%D 2015
%U http://hdl.handle.net/10668/9750
%X Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (PHis substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcɛRI pathway in this pathology.
%K Polymorphism, Single Nucleotide
%K Protein Structure, Tertiary
%K Spain
%K beta-Lactams
%K Blood Proteins
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