RT Journal Article
T1 A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics.
A1 Cornejo-Garcia, J A
A1 Romano, A
A1 Gueant-Rodriguez, R M
A1 Oussalah, A
A1 Blanca-Lopez, N
A1 Gaeta, F
A1 Tramoy, D
A1 Josse, T
A1 Doña, I
A1 Torres, M J
A1 Canto, G
A1 Blanca, M
A1 Gueant, J-L
K1 Polymorphism, Single Nucleotide
K1 Protein Structure, Tertiary
K1 Spain
K1 beta-Lactams
K1 Blood Proteins
AB Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (PHis substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcɛRI pathway in this pathology.
PB Nature Publishing Group
YR 2015
FD 2015-04-14
LK http://hdl.handle.net/10668/9750
UL http://hdl.handle.net/10668/9750
LA en
NO Cornejo-García JA, Romano A, Guéant-Rodríguez RM, Oussalah A, Blanca-López N, Gaeta F, et al.  A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics. Pharmacogenomics J. 2016 Feb;16(1):79-82
NO Manuscript was supported in part by Grants from Inserm, the Lorraine Region and PHRC (Hospital clinical research program, 2012, PHRC 189), and from Spanish Ministry Fund for Health in Spain (FIS) network RIRAAF (RD12/0013), and PS09/02419.
DS RISalud
RD Apr 7, 2025