Publication: Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy.
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Date
2018-12-08
Authors
García-Aranda, Marilina
Pérez-Ruiz, Elisabet
Redondo, Maximino
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Abstract
Abstract: According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to overcome resistance to chemo- and immunotherapy.
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MeSH Terms
Animals
Apoptosis
Drug Resistance, Neoplasm
Humans
Immunotherapy
Models, Biological
Neoplasms
Proto-Oncogene Proteins c-bcl-2
Apoptosis
Drug Resistance, Neoplasm
Humans
Immunotherapy
Models, Biological
Neoplasms
Proto-Oncogene Proteins c-bcl-2
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Keywords
Bcl-2, apoptosis, cancer, chemotherapy, immunotherapy, inhibition, resistance