RT Journal Article
T1 Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy.
A1 García-Aranda, Marilina
A1 Pérez-Ruiz, Elisabet
A1 Redondo, Maximino
K1 Bcl-2
K1 apoptosis
K1 cancer
K1 chemotherapy
K1 immunotherapy
K1 inhibition
K1 resistance
AB Abstract: According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to overcome resistance to chemo- and immunotherapy.
YR 2018
FD 2018-12-08
LK http://hdl.handle.net/10668/13309
UL http://hdl.handle.net/10668/13309
LA en
DS RISalud
RD Apr 8, 2025