Publication:
Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy.

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dc.contributor.authorGarcía-Aranda, Marilina
dc.contributor.authorPérez-Ruiz, Elisabet
dc.contributor.authorRedondo, Maximino
dc.date.accessioned2023-01-25T10:26:16Z
dc.date.available2023-01-25T10:26:16Z
dc.date.issued2018-12-08
dc.description.abstractAbstract: According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to overcome resistance to chemo- and immunotherapy.
dc.identifier.doi10.3390/ijms19123950
dc.identifier.essn1422-0067
dc.identifier.pmcPMC6321604
dc.identifier.pmid30544835
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321604/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/1422-0067/19/12/3950/pdf
dc.identifier.urihttp://hdl.handle.net/10668/13309
dc.issue.number12
dc.journal.titleInternational journal of molecular sciences
dc.journal.titleabbreviationInt J Mol Sci
dc.language.isoen
dc.organizationHospital Costa del Sol
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBcl-2
dc.subjectapoptosis
dc.subjectcancer
dc.subjectchemotherapy
dc.subjectimmunotherapy
dc.subjectinhibition
dc.subjectresistance
dc.subject.meshAnimals
dc.subject.meshApoptosis
dc.subject.meshDrug Resistance, Neoplasm
dc.subject.meshHumans
dc.subject.meshImmunotherapy
dc.subject.meshModels, Biological
dc.subject.meshNeoplasms
dc.subject.meshProto-Oncogene Proteins c-bcl-2
dc.titleBcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number19
dspace.entity.typePublication

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