%0 Journal Article
%A García-Aranda, Marilina
%A Pérez-Ruiz, Elisabet
%A Redondo, Maximino
%T Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy.
%D 2018
%U http://hdl.handle.net/10668/13309
%X Abstract: According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to overcome resistance to chemo- and immunotherapy.
%K Bcl-2
%K apoptosis
%K cancer
%K chemotherapy
%K immunotherapy
%K inhibition
%K resistance
%~