Publication: Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.
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Identifiers
Date
2019-01-08
Authors
Rogati, Federica
Millan, Estrella
Appendino, Giovanni
Correa, Alejandro
Caprioglio, Diego
Minassi, Alberto
Muñoz, Eduardo
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
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Abstract
The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.
Description
MeSH Terms
NF-kappa B
Ether
Plant growth regulators
Butenolide
NF-E2-related factor 2
Critical pathways
Ethyl ethers
Ether
Plant growth regulators
Butenolide
NF-E2-related factor 2
Critical pathways
Ethyl ethers
DeCS Terms
FN-kappa B
Factor 2 relacionado con NF-E2
Reguladores del crecimiento de las plantas
Vías clínicas
Éter
Éteres de etila
Factor 2 relacionado con NF-E2
Reguladores del crecimiento de las plantas
Vías clínicas
Éter
Éteres de etila
CIE Terms
Keywords
Strigolactones, Terpenes, Nrf2, NF-κB
Citation
Rogati F, Millán E, Appendino G, Correa A, Caprioglio D, Minassi A, et al. Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity. ACS Med Chem Lett. 2019 Jan 8;10(4):606-610