%0 Journal Article
%A Rogati, Federica
%A Millan, Estrella
%A Appendino, Giovanni
%A Correa, Alejandro
%A Caprioglio, Diego
%A Minassi, Alberto
%A Muñoz, Eduardo
%T Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.
%D 2019
%@ 1948-5875
%U http://hdl.handle.net/10668/13847
%X The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.
%K Strigolactones
%K Terpenes
%K Nrf2
%K NF-κB
%~