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Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.

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dc.contributor.authorRogati, Federica
dc.contributor.authorMillan, Estrella
dc.contributor.authorAppendino, Giovanni
dc.contributor.authorCorrea, Alejandro
dc.contributor.authorCaprioglio, Diego
dc.contributor.authorMinassi, Alberto
dc.contributor.authorMuñoz, Eduardo
dc.date.accessioned2023-01-25T13:32:46Z
dc.date.available2023-01-25T13:32:46Z
dc.date.issued2019-01-08
dc.description.abstractThe sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.
dc.identifier.citationRogati F, Millán E, Appendino G, Correa A, Caprioglio D, Minassi A, et al. Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity. ACS Med Chem Lett. 2019 Jan 8;10(4):606-610
dc.identifier.doi10.1021/acsmedchemlett.8b00604
dc.identifier.issn1948-5875
dc.identifier.pmcPMC6467025
dc.identifier.pmid30996804
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467025/pdf
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc6467025?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/13847
dc.issue.number4
dc.journal.titleACS medicinal chemistry letters
dc.journal.titleabbreviationACS Med Chem Lett
dc.language.isoen
dc.organizationHospital Universitario Reina Sofía
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba-IMIBIC
dc.page.number606-610
dc.publisherAmerican Chemical Society
dc.pubmedtypeJournal Article
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00604
dc.rights.accessRightsopen access
dc.subjectStrigolactones
dc.subjectTerpenes
dc.subjectNrf2
dc.subjectNF-κB
dc.subject.decsFN-kappa B
dc.subject.decsFactor 2 relacionado con NF-E2
dc.subject.decsReguladores del crecimiento de las plantas
dc.subject.decsVías clínicas
dc.subject.decsÉter
dc.subject.decsÉteres de etila
dc.subject.meshNF-kappa B
dc.subject.meshEther
dc.subject.meshPlant growth regulators
dc.subject.meshButenolide
dc.subject.meshNF-E2-related factor 2
dc.subject.meshCritical pathways
dc.subject.meshEthyl ethers
dc.titleIdentification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication

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