RT Journal Article
T1 Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.
A1 Rogati, Federica
A1 Millan, Estrella
A1 Appendino, Giovanni
A1 Correa, Alejandro
A1 Caprioglio, Diego
A1 Minassi, Alberto
A1 Muñoz, Eduardo
K1 Strigolactones
K1 Terpenes
K1 Nrf2
K1 NF-κB
AB The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.
PB American Chemical Society
SN 1948-5875
YR 2019
FD 2019-01-08
LK http://hdl.handle.net/10668/13847
UL http://hdl.handle.net/10668/13847
LA en
NO Rogati F, Millán E, Appendino G, Correa A, Caprioglio D, Minassi A, et al.   Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity. ACS Med Chem Lett. 2019 Jan 8;10(4):606-610
DS RISalud
RD Apr 18, 2025