Publication: Impact of DARC rs12075 Variants on Liver Fibrosis Progression in Patients with Chronic Hepatitis C: A Retrospective Study.
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2019-04-09
Authors
Jiménez-Sousa, María Ángeles
Gómez-Moreno, Ana Zaida
Pineda-Tenor, Daniel
Sánchez-Ruano, Juan José
Artaza-Varasa, Tomas
Martin-Vicente, María
Fernández-Rodríguez, Amanda
Martínez, Isidoro
Resino, Salvador
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Abstract
: The Duffy antigen receptor for chemokines (DARC) rs12075 polymorphism regulates leukocyte trafficking and proinflammatory chemokine homeostasis. Hepatitis C virus (HCV)-mediated liver fibrosis is associated with an uncontrolled inflammatory response. In this study, we evaluate the association between the DARC rs12075 polymorphism and liver stiffness progression in HCV-infected patients. We carried out a retrospective cohort study (repeated measures design) in 208 noncirrhotic patients with chronic hepatitis C (CHC) who had at least two liver stiffness measurements (LSM) with a separation of at least 12 months. We used generalized linear models to analyze the association between DARC rs12075 polymorphism and outcome variables. During a follow-up of 46.6 months, the percentage of patients with stages of fibrosis F0/F1 decreased (p
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MeSH Terms
Adult
Duffy Blood-Group System
Female
Hepatitis C, Chronic
Humans
Liver
Liver Cirrhosis
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Cell Surface
Duffy Blood-Group System
Female
Hepatitis C, Chronic
Humans
Liver
Liver Cirrhosis
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Cell Surface
DeCS Terms
CIE Terms
Keywords
DARC, chronic hepatitis C, cirrhosis, hepatic fibrosis, liver stiffness, single nucleotide polymorphisms