Publication:
Impact of DARC rs12075 Variants on Liver Fibrosis Progression in Patients with Chronic Hepatitis C: A Retrospective Study.

Simple item page
dc.contributor.authorJiménez-Sousa, María Ángeles
dc.contributor.authorGómez-Moreno, Ana Zaida
dc.contributor.authorPineda-Tenor, Daniel
dc.contributor.authorSánchez-Ruano, Juan José
dc.contributor.authorArtaza-Varasa, Tomas
dc.contributor.authorMartin-Vicente, María
dc.contributor.authorFernández-Rodríguez, Amanda
dc.contributor.authorMartínez, Isidoro
dc.contributor.authorResino, Salvador
dc.date.accessioned2023-01-25T13:32:35Z
dc.date.available2023-01-25T13:32:35Z
dc.date.issued2019-04-09
dc.description.abstract: The Duffy antigen receptor for chemokines (DARC) rs12075 polymorphism regulates leukocyte trafficking and proinflammatory chemokine homeostasis. Hepatitis C virus (HCV)-mediated liver fibrosis is associated with an uncontrolled inflammatory response. In this study, we evaluate the association between the DARC rs12075 polymorphism and liver stiffness progression in HCV-infected patients. We carried out a retrospective cohort study (repeated measures design) in 208 noncirrhotic patients with chronic hepatitis C (CHC) who had at least two liver stiffness measurements (LSM) with a separation of at least 12 months. We used generalized linear models to analyze the association between DARC rs12075 polymorphism and outcome variables. During a follow-up of 46.6 months, the percentage of patients with stages of fibrosis F0/F1 decreased (p
dc.identifier.doi10.3390/biom9040143
dc.identifier.essn2218-273X
dc.identifier.pmcPMC6523653
dc.identifier.pmid30970632
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523653/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2218-273X/9/4/143/pdf?version=1555669940
dc.identifier.urihttp://hdl.handle.net/10668/13809
dc.issue.number4
dc.journal.titleBiomolecules
dc.journal.titleabbreviationBiomolecules
dc.language.isoen
dc.organizationÁrea de Gestión Sanitaria Norte de Málaga
dc.organizationAGS - Norte de Málaga
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDARC
dc.subjectchronic hepatitis C
dc.subjectcirrhosis
dc.subjecthepatic fibrosis
dc.subjectliver stiffness
dc.subjectsingle nucleotide polymorphisms
dc.subject.meshAdult
dc.subject.meshDuffy Blood-Group System
dc.subject.meshFemale
dc.subject.meshHepatitis C, Chronic
dc.subject.meshHumans
dc.subject.meshLiver
dc.subject.meshLiver Cirrhosis
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshReceptors, Cell Surface
dc.titleImpact of DARC rs12075 Variants on Liver Fibrosis Progression in Patients with Chronic Hepatitis C: A Retrospective Study.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
PMC6523653.pdf
Size:
1.07 MB
Format:
Adobe Portable Document Format
Download

Collections

SAS - Hospital de Antequera

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía