%0 Journal Article
%A Jiménez-Sousa, María Ángeles
%A Gómez-Moreno, Ana Zaida
%A Pineda-Tenor, Daniel
%A Sánchez-Ruano, Juan José
%A Artaza-Varasa, Tomas
%A Martin-Vicente, María
%A Fernández-Rodríguez, Amanda
%A Martínez, Isidoro
%A Resino, Salvador
%T Impact of DARC rs12075 Variants on Liver Fibrosis Progression in Patients with Chronic Hepatitis C: A Retrospective Study.
%D 2019
%U http://hdl.handle.net/10668/13809
%X : The Duffy antigen receptor for chemokines (DARC) rs12075 polymorphism regulates leukocyte trafficking and proinflammatory chemokine homeostasis. Hepatitis C virus (HCV)-mediated liver fibrosis is associated with an uncontrolled inflammatory response. In this study, we evaluate the association between the DARC rs12075 polymorphism and liver stiffness progression in HCV-infected patients. We carried out a retrospective cohort study (repeated measures design) in 208 noncirrhotic patients with chronic hepatitis C (CHC) who had at least two liver stiffness measurements (LSM) with a separation of at least 12 months. We used generalized linear models to analyze the association between DARC rs12075 polymorphism and outcome variables. During a follow-up of 46.6 months, the percentage of patients with stages of fibrosis F0/F1 decreased (p
%K DARC
%K chronic hepatitis C
%K cirrhosis
%K hepatic fibrosis
%K liver stiffness
%K single nucleotide polymorphisms
%~