RT Journal Article
T1 Impact of DARC rs12075 Variants on Liver Fibrosis Progression in Patients with Chronic Hepatitis C: A Retrospective Study.
A1 Jiménez-Sousa, María Ángeles
A1 Gómez-Moreno, Ana Zaida
A1 Pineda-Tenor, Daniel
A1 Sánchez-Ruano, Juan José
A1 Artaza-Varasa, Tomas
A1 Martin-Vicente, María
A1 Fernández-Rodríguez, Amanda
A1 Martínez, Isidoro
A1 Resino, Salvador
K1 DARC
K1 chronic hepatitis C
K1 cirrhosis
K1 hepatic fibrosis
K1 liver stiffness
K1 single nucleotide polymorphisms
AB : The Duffy antigen receptor for chemokines (DARC) rs12075 polymorphism regulates leukocyte trafficking and proinflammatory chemokine homeostasis. Hepatitis C virus (HCV)-mediated liver fibrosis is associated with an uncontrolled inflammatory response. In this study, we evaluate the association between the DARC rs12075 polymorphism and liver stiffness progression in HCV-infected patients. We carried out a retrospective cohort study (repeated measures design) in 208 noncirrhotic patients with chronic hepatitis C (CHC) who had at least two liver stiffness measurements (LSM) with a separation of at least 12 months. We used generalized linear models to analyze the association between DARC rs12075 polymorphism and outcome variables. During a follow-up of 46.6 months, the percentage of patients with stages of fibrosis F0/F1 decreased (p
YR 2019
FD 2019-04-09
LK http://hdl.handle.net/10668/13809
UL http://hdl.handle.net/10668/13809
LA en
DS RISalud
RD Apr 6, 2025