Publication: Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations.
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Identifiers
Date
2022-11-14
Authors
Alcala-Santiago, Angela
Rodriguez-Barranco, Miguel
Rava, Marta
Jimenez-Sousa, Maria Angeles
Gil, Angel
Sanchez-Perez, Maria-Jose
Molina-Montes, Esther
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Publisher
MDPI AG
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Abstract
Vitamin D (VD) is a fat-soluble vitamin, and pivotal for maintaining health. Several genetic markers have been related to a deficient VD status; these markers could confer an increased risk to develop osteoporosis and other chronic diseases. A VD deficiency could also be a determinant of a severe COVID-19 disease. This study aimed to interrogate genetic/biological databases on the biological implications of a VD deficiency and its association with diseases, to further explore its link with COVID-19. The genetic variants of both a VD deficiency and COVID-19 were identified in the genome-wide association studies (GWAS) catalog and other sources. We conducted enrichment analyses (considering corrected p-values
Description
MeSH Terms
Humans
COVID-19
Genome-Wide Association Study
Vitamin D Deficiency
Vitamin D
Vitamins
COVID-19
Genome-Wide Association Study
Vitamin D Deficiency
Vitamin D
Vitamins
DeCS Terms
Deficiencia de Vitamina D
Estudio de asociación del genoma completo
Vitaminas
Vitamina D
Humanos
Estudio de asociación del genoma completo
Vitaminas
Vitamina D
Humanos
CIE Terms
Keywords
COVID-19, SARS-CoV-2, computational biology, genes, nutrition, vitamin D
Citation
Alcalá-Santiago Á, Rodríguez-Barranco M, Rava M, Jiménez-Sousa MÁ, Gil Á, Sánchez MJ, et al. Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations. Int J Mol Sci. 2022 Nov 17;23(22):14256.