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Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations.

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dc.contributor.authorAlcala-Santiago, Angela
dc.contributor.authorRodriguez-Barranco, Miguel
dc.contributor.authorRava, Marta
dc.contributor.authorJimenez-Sousa, Maria Angeles
dc.contributor.authorGil, Angel
dc.contributor.authorSanchez-Perez, Maria-Jose
dc.contributor.authorMolina-Montes, Esther
dc.contributor.fundery Consejería de Salud de la Junta de Andalucía
dc.contributor.funderEuropean Regional Development Fund (ERDF-FEDER)
dc.date.accessioned2023-05-03T14:04:02Z
dc.date.available2023-05-03T14:04:02Z
dc.date.issued2022-11-14
dc.description.abstractVitamin D (VD) is a fat-soluble vitamin, and pivotal for maintaining health. Several genetic markers have been related to a deficient VD status; these markers could confer an increased risk to develop osteoporosis and other chronic diseases. A VD deficiency could also be a determinant of a severe COVID-19 disease. This study aimed to interrogate genetic/biological databases on the biological implications of a VD deficiency and its association with diseases, to further explore its link with COVID-19. The genetic variants of both a VD deficiency and COVID-19 were identified in the genome-wide association studies (GWAS) catalog and other sources. We conducted enrichment analyses (considering corrected p-values
dc.description.sponsorshipThis research was funded by Project PECOVID-0200-2020, funded by Consejería de Salud de la Junta de Andalucía and co-funded by the European Regional Development Fund (ERDF-FEDER).
dc.description.versionSi
dc.identifier.citationAlcalá-Santiago Á, Rodríguez-Barranco M, Rava M, Jiménez-Sousa MÁ, Gil Á, Sánchez MJ, et al. Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations. Int J Mol Sci. 2022 Nov 17;23(22):14256.
dc.identifier.doi10.3390/ijms232214256
dc.identifier.essn1422-0067
dc.identifier.pmcPMC9699081
dc.identifier.pmid36430729
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699081/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/1422-0067/23/22/14256/pdf?version=1668755078
dc.identifier.urihttp://hdl.handle.net/10668/21217
dc.issue.number22
dc.journal.titleInternational journal of molecular sciences
dc.journal.titleabbreviationInt J Mol Sci
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.publisherMDPI AG
dc.pubmedtypeJournal Article
dc.relation.projectIDPECOVID-0200-2020
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=ijms232214256
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectcomputational biology
dc.subjectgenes
dc.subjectnutrition
dc.subjectvitamin D
dc.subject.decsDeficiencia de Vitamina D
dc.subject.decsEstudio de asociación del genoma completo
dc.subject.decsVitaminas
dc.subject.decsVitamina D
dc.subject.decsHumanos
dc.subject.meshHumans
dc.subject.meshCOVID-19
dc.subject.meshGenome-Wide Association Study
dc.subject.meshVitamin D Deficiency
dc.subject.meshVitamin D
dc.subject.meshVitamins
dc.titleVitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number23
dspace.entity.typePublication

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