Publication: A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin.
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2021-04-14
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Gómez-González, Belen
Sessa, Gaetana
Carreira, Aura
Aguilera, Andrés
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Abstract
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2-DDX5 interaction is impaired in cells expressing the BRCA2T207A missense variant found in breast cancer patients.
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BRCA2, DDX5, DNA-RNA hybrid, DSB repair, breast cancer, double-strand break, homologous recombination