RT Journal Article
T1 A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin.
A1 Gómez-González, Belen
A1 Sessa, Gaetana
A1 Carreira, Aura
A1 Aguilera, Andrés
K1 BRCA2
K1 DDX5
K1 DNA-RNA hybrid
K1 DSB repair
K1 breast cancer
K1 double-strand break
K1 homologous recombination
AB In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2-DDX5 interaction is impaired in cells expressing the BRCA2T207A missense variant found in breast cancer patients.
SN 2372-3556
YR 2021
FD 2021-04-14
LK http://hdl.handle.net/10668/17824
UL http://hdl.handle.net/10668/17824
LA en
DS RISalud
RD Apr 8, 2025