%0 Journal Article
%A Gómez-González, Belen
%A Sessa, Gaetana
%A Carreira, Aura
%A Aguilera, Andrés
%T A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin.
%D 2021
%@ 2372-3556
%U http://hdl.handle.net/10668/17824
%X In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2-DDX5 interaction is impaired in cells expressing the BRCA2T207A missense variant found in breast cancer patients.
%K BRCA2
%K DDX5
%K DNA-RNA hybrid
%K DSB repair
%K breast cancer
%K double-strand break
%K homologous recombination
%~