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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin.

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dc.contributor.authorGómez-González, Belen
dc.contributor.authorSessa, Gaetana
dc.contributor.authorCarreira, Aura
dc.contributor.authorAguilera, Andrés
dc.date.accessioned2023-02-09T11:38:50Z
dc.date.available2023-02-09T11:38:50Z
dc.date.issued2021-04-14
dc.description.abstractIn a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2-DDX5 interaction is impaired in cells expressing the BRCA2T207A missense variant found in breast cancer patients.
dc.identifier.doi10.1080/23723556.2021.1910474
dc.identifier.issn2372-3556
dc.identifier.pmcPMC8128217
dc.identifier.pmid34027046
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128217/pdf
dc.identifier.unpaywallURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128217
dc.identifier.urihttp://hdl.handle.net/10668/17824
dc.issue.number3
dc.journal.titleMolecular & cellular oncology
dc.journal.titleabbreviationMol Cell Oncol
dc.language.isoen
dc.organizationCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER
dc.page.number1910474
dc.pubmedtypeJournal Article
dc.rights.accessRightsopen access
dc.subjectBRCA2
dc.subjectDDX5
dc.subjectDNA-RNA hybrid
dc.subjectDSB repair
dc.subjectbreast cancer
dc.subjectdouble-strand break
dc.subjecthomologous recombination
dc.titleA new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number8
dspace.entity.typePublication

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