Publication: Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol.
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Date
2021-08-22
Authors
Domínguez-López, Inés
Parilli-Moser, Isabella
Arancibia-Riveros, Camila
Tresserra-Rimbau, Anna
Martínez-González, Miguel Angel
Ortega-Azorín, Carolina
Salas-Salvadó, Jordi
Castañer, Olga
Lapetra, José
Arós, Fernando
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Abstract
Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevención con Dieta Mediterránea) trial included a sample of 230 women aged 60-80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 μg/mg (95% confidence interval (CI): 0.01, 0.01), p-value
Description
MeSH Terms
Aged
Aged, 80 and over
Alcohol Drinking
Anthropometry
Biomarkers
Cardiovascular Diseases
Cholesterol
Cholesterol, LDL
Cross-Sectional Studies
Female
Heart Disease Risk Factors
Humans
Middle Aged
Randomized Controlled Trials as Topic
Tartrates
Wine
Aged, 80 and over
Alcohol Drinking
Anthropometry
Biomarkers
Cardiovascular Diseases
Cholesterol
Cholesterol, LDL
Cross-Sectional Studies
Female
Heart Disease Risk Factors
Humans
Middle Aged
Randomized Controlled Trials as Topic
Tartrates
Wine
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Keywords
Mediterranean diet, PREDIMED, biomarkers, body fat, cardiovascular risk, lipid profile, menopause, polyphenols, tartaric acid