Publication: AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome.
No Thumbnail Available
Identifiers
Date
2016-01-19
Authors
Bullon, Pedro
Alcocer-Gomez, Elisabet
Carrion, Angel M
Marin-Aguilar, Fabiola
Garrido-Maraver, Juan
Roman-Malo, Lourdes
Ruiz-Cabello, Jesus
Culic, Ognjen
Ryffel, Bernhard
Apetoh, Lionel
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Mary Ann Liebert, Inc. Publishers
Metrics
Export
Abstract
Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic and inflammatory diseases. In this study, we investigated the role of AMPK/NLRP3 inflammasome axis in the molecular mechanism underlying pain perception. Impairment in AMPK activation induced by compound C or sunitinib, two AMPK inhibitors, provoked hyperalgesia in mice (p These data suggest that AMPK/NLRP3 inflammasome axis participates in chronic pain and that NLRP3 inflammasome inhibition by AMPK modulation may be a novel therapeutic target to fight against chronic pain and inflammatory diseases as FM.
Description
MeSH Terms
Adult
Animals
Female
Humans
Indoles
Inflammasomes
Interleukin-1beta
Male
Metformin
Middle Aged
NLR Family, Pyrin Domain-Containing 3 Protein
Pain
Phosphorylation
Pyrroles
Animals
Female
Humans
Indoles
Inflammasomes
Interleukin-1beta
Male
Metformin
Middle Aged
NLR Family, Pyrin Domain-Containing 3 Protein
Pain
Phosphorylation
Pyrroles
DeCS Terms
Inflamasomas
Dolor crónico
Hiperalgesia
Proteínas Quinasas
Dominio Pirina
Terapéutica
Sunitinib
Adenosina monofosfato
Proteínas NLR
Dolor crónico
Hiperalgesia
Proteínas Quinasas
Dominio Pirina
Terapéutica
Sunitinib
Adenosina monofosfato
Proteínas NLR
CIE Terms
Keywords
AMP-Activated Protein Kinases, Carrier Proteins, Fibromyalgia, Interleukin-18, Mice, Pain Perception, Sunitinib
Citation
Bullón P, Alcocer-Gómez E, Carrión AM, Marín-Aguilar F, Garrido-Maraver J, Román-Malo L, et al. AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome. Antioxid Redox Signal. 2016 Jan 20;24(3):157-70.