%0 Journal Article
%A Bullon, Pedro
%A Alcocer-Gomez, Elisabet
%A Carrion, Angel M
%A Marin-Aguilar, Fabiola
%A Garrido-Maraver, Juan
%A Roman-Malo, Lourdes
%A Ruiz-Cabello, Jesus
%A Culic, Ognjen
%A Ryffel, Bernhard
%A Apetoh, Lionel
%A Ghiringhelli, François
%A Battino, Maurizio
%A Sanchez-Alcazar, Jose Antonio
%A Cordero, Mario D
%T AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome.
%D 2016
%U http://hdl.handle.net/10668/9927
%X Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic and inflammatory diseases. In this study, we investigated the role of AMPK/NLRP3 inflammasome axis in the molecular mechanism underlying pain perception. Impairment in AMPK activation induced by compound C or sunitinib, two AMPK inhibitors, provoked hyperalgesia in mice (p These data suggest that AMPK/NLRP3 inflammasome axis participates in chronic pain and that NLRP3 inflammasome inhibition by AMPK modulation may be a novel therapeutic target to fight against chronic pain and inflammatory diseases as FM.
%K AMP-Activated Protein Kinases
%K Carrier Proteins
%K Fibromyalgia
%K Interleukin-18
%K Mice
%K Pain Perception
%K Sunitinib
%~