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AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome.

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dc.contributor.authorBullon, Pedro
dc.contributor.authorAlcocer-Gomez, Elisabet
dc.contributor.authorCarrion, Angel M
dc.contributor.authorMarin-Aguilar, Fabiola
dc.contributor.authorGarrido-Maraver, Juan
dc.contributor.authorRoman-Malo, Lourdes
dc.contributor.authorRuiz-Cabello, Jesus
dc.contributor.authorCulic, Ognjen
dc.contributor.authorRyffel, Bernhard
dc.contributor.authorApetoh, Lionel
dc.contributor.authorGhiringhelli, François
dc.contributor.authorBattino, Maurizio
dc.contributor.authorSanchez-Alcazar, Jose Antonio
dc.contributor.authorCordero, Mario D
dc.date.accessioned2023-01-25T08:31:25Z
dc.date.available2023-01-25T08:31:25Z
dc.date.issued2016-01-19
dc.description.abstractImpairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic and inflammatory diseases. In this study, we investigated the role of AMPK/NLRP3 inflammasome axis in the molecular mechanism underlying pain perception. Impairment in AMPK activation induced by compound C or sunitinib, two AMPK inhibitors, provoked hyperalgesia in mice (p These data suggest that AMPK/NLRP3 inflammasome axis participates in chronic pain and that NLRP3 inflammasome inhibition by AMPK modulation may be a novel therapeutic target to fight against chronic pain and inflammatory diseases as FM.
dc.description.versionSi
dc.identifier.citationBullón P, Alcocer-Gómez E, Carrión AM, Marín-Aguilar F, Garrido-Maraver J, Román-Malo L, et al. AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome. Antioxid Redox Signal. 2016 Jan 20;24(3):157-70.
dc.identifier.doi10.1089/ars.2014.6120
dc.identifier.essn1557-7716
dc.identifier.pmcPMC4742979
dc.identifier.pmid26132721
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742979/pdf
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc4742979?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/9927
dc.issue.number3
dc.journal.titleAntioxidants & redox signaling
dc.journal.titleabbreviationAntioxid Redox Signal
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.page.number157-170
dc.provenanceRealizada la curación de contenido 12/03/2025
dc.publisherMary Ann Liebert, Inc. Publishers
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.publisherversionhttps://www.liebertpub.com/doi/10.1089/ars.2014.6120?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.rights.accessRightsRestricted Access
dc.subjectAMP-Activated Protein Kinases
dc.subjectCarrier Proteins
dc.subjectFibromyalgia
dc.subjectInterleukin-18
dc.subjectMice
dc.subjectPain Perception
dc.subjectSunitinib
dc.subject.decsInflamasomas
dc.subject.decsDolor crónico
dc.subject.decsHiperalgesia
dc.subject.decsProteínas Quinasas
dc.subject.decsDominio Pirina
dc.subject.decsTerapéutica
dc.subject.decsSunitinib
dc.subject.decsAdenosina monofosfato
dc.subject.decsProteínas NLR
dc.subject.meshAdult
dc.subject.meshAnimals
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIndoles
dc.subject.meshInflammasomes
dc.subject.meshInterleukin-1beta
dc.subject.meshMale
dc.subject.meshMetformin
dc.subject.meshMiddle Aged
dc.subject.meshNLR Family, Pyrin Domain-Containing 3 Protein
dc.subject.meshPain
dc.subject.meshPhosphorylation
dc.subject.meshPyrroles
dc.titleAMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number24
dspace.entity.typePublication

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