RT Journal Article
T1 AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome.
A1 Bullon, Pedro
A1 Alcocer-Gomez, Elisabet
A1 Carrion, Angel M
A1 Marin-Aguilar, Fabiola
A1 Garrido-Maraver, Juan
A1 Roman-Malo, Lourdes
A1 Ruiz-Cabello, Jesus
A1 Culic, Ognjen
A1 Ryffel, Bernhard
A1 Apetoh, Lionel
A1 Ghiringhelli, François
A1 Battino, Maurizio
A1 Sanchez-Alcazar, Jose Antonio
A1 Cordero, Mario D
K1 AMP-Activated Protein Kinases
K1 Carrier Proteins
K1 Fibromyalgia
K1 Interleukin-18
K1 Mice
K1 Pain Perception
K1 Sunitinib
AB Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic and inflammatory diseases. In this study, we investigated the role of AMPK/NLRP3 inflammasome axis in the molecular mechanism underlying pain perception. Impairment in AMPK activation induced by compound C or sunitinib, two AMPK inhibitors, provoked hyperalgesia in mice (p These data suggest that AMPK/NLRP3 inflammasome axis participates in chronic pain and that NLRP3 inflammasome inhibition by AMPK modulation may be a novel therapeutic target to fight against chronic pain and inflammatory diseases as FM.
PB Mary Ann Liebert, Inc. Publishers
YR 2016
FD 2016-01-19
LK http://hdl.handle.net/10668/9927
UL http://hdl.handle.net/10668/9927
LA en
NO Bullón P, Alcocer-Gómez E, Carrión AM, Marín-Aguilar F, Garrido-Maraver J, Román-Malo L, et al. AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome. Antioxid Redox Signal. 2016 Jan 20;24(3):157-70.
DS RISalud
RD Apr 14, 2025