Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity.
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2021-10-06
Authors
Cárdenas, Casimiro
Torres-Vargas, José Antonio
Cárdenas-Valdivia, Abel
Jurado, Nuria
Quesada, Ana R
García-Caballero, Melissa
Martínez-Poveda, Beatriz
Medina, Miguel Ángel
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Abstract
The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.
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MeSH Terms
Angiogenesis Inhibitors
Animals
Annona
Cattle
Cell Differentiation
Cell Movement
Cells, Cultured
Chromatography, High Pressure Liquid
Endothelial Cells
Metabolome
Metabolomics
Neovascularization, Physiologic
Phytochemicals
Plant Extracts
Plant Leaves
Spectrometry, Mass, Electrospray Ionization
Animals
Annona
Cattle
Cell Differentiation
Cell Movement
Cells, Cultured
Chromatography, High Pressure Liquid
Endothelial Cells
Metabolome
Metabolomics
Neovascularization, Physiologic
Phytochemicals
Plant Extracts
Plant Leaves
Spectrometry, Mass, Electrospray Ionization
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Keywords
Angiogenesis, Annona muricata, Graviola, Soursop, Ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC–HRMS)