Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity.

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dc.contributor.authorCárdenas, Casimiro
dc.contributor.authorTorres-Vargas, José Antonio
dc.contributor.authorCárdenas-Valdivia, Abel
dc.contributor.authorJurado, Nuria
dc.contributor.authorQuesada, Ana R
dc.contributor.authorGarcía-Caballero, Melissa
dc.contributor.authorMartínez-Poveda, Beatriz
dc.contributor.authorMedina, Miguel Ángel
dc.date.accessioned2025-01-07T15:51:24Z
dc.date.available2025-01-07T15:51:24Z
dc.date.issued2021-10-06
dc.description.abstractThe tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.
dc.identifier.doi10.1016/j.biopha.2021.112263
dc.identifier.essn1950-6007
dc.identifier.pmid34626933
dc.identifier.unpaywallURLhttps://doi.org/10.1016/j.biopha.2021.112263
dc.identifier.urihttps://hdl.handle.net/10668/27454
dc.journal.titleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
dc.journal.titleabbreviationBiomed Pharmacother
dc.language.isoen
dc.organizationInstituto de Investigación Biomédica de Málaga - Plataforma Bionand (IBIMA)
dc.page.number112263
dc.pubmedtypeJournal Article
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAngiogenesis
dc.subjectAnnona muricata
dc.subjectGraviola
dc.subjectSoursop
dc.subjectUltra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC–HRMS)
dc.subject.meshAngiogenesis Inhibitors
dc.subject.meshAnimals
dc.subject.meshAnnona
dc.subject.meshCattle
dc.subject.meshCell Differentiation
dc.subject.meshCell Movement
dc.subject.meshCells, Cultured
dc.subject.meshChromatography, High Pressure Liquid
dc.subject.meshEndothelial Cells
dc.subject.meshMetabolome
dc.subject.meshMetabolomics
dc.subject.meshNeovascularization, Physiologic
dc.subject.meshPhytochemicals
dc.subject.meshPlant Extracts
dc.subject.meshPlant Leaves
dc.subject.meshSpectrometry, Mass, Electrospray Ionization
dc.titleNon-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number144

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