RT Journal Article
T1 Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity.
A1 Cárdenas, Casimiro
A1 Torres-Vargas, José Antonio
A1 Cárdenas-Valdivia, Abel
A1 Jurado, Nuria
A1 Quesada, Ana R
A1 García-Caballero, Melissa
A1 Martínez-Poveda, Beatriz
A1 Medina, Miguel Ángel
K1 Angiogenesis
K1 Annona muricata
K1 Graviola
K1 Soursop
K1 Ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC–HRMS)
AB The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.
YR 2021
FD 2021-10-06
LK https://hdl.handle.net/10668/27454
UL https://hdl.handle.net/10668/27454
LA en
DS RISalud
RD Apr 7, 2025