Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet
No Thumbnail Available
Identifiers
Date
2021-07-22
Authors
Razquin, Cristina
Ruiz-Canela, Miguel
Toledo, Estefania
Hernandez-Alonso, Pablo
Clish, Clary B.
Guasch-Ferre, Marta
Li, Jun
Wittenbecher, Clemens
Dennis, Courtney
Alonso-Gomez, Angel
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford univ press
Metrics
Export
Abstract
Background: The tryptophan-kynurenine pathway is linked to inflammation. We hypothesize that metabolites implicated in this pathway may be associated with the risk of heart failure (HF) or atrial fibrillation (AF) in a population at high risk of cardiovascular disease.Objectives: We aimed to prospectively analyze the associations of kynurenine-related metabolites with the risk of HF and AF and to analyze a potential effect modification by the randomized interventions of the PREDIMED (Prevencion con Dieta MediterrAnea) trial with Mediterranean diet (MedDiet).Methods: Two case-control studies nested within the PREDIMED trial were designed. We selected 324 incident HF cases and 502 incident AF cases individually matched with
Description
MeSH Terms
DeCS Terms
CIE Terms
Keywords
tryptophan, kynurenine, heart failure, atrial fibrillation, metabolomics, Mediterranean diet, case-control, PREDIMED, Cardiovascular-disease, Olive oil, Inflammation, Biomarkers, Predictors, Cancer, Adults