RT Journal Article
T1 Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet
A1 Razquin, Cristina
A1 Ruiz-Canela, Miguel
A1 Toledo, Estefania
A1 Hernandez-Alonso, Pablo
A1 Clish, Clary B.
A1 Guasch-Ferre, Marta
A1 Li, Jun
A1 Wittenbecher, Clemens
A1 Dennis, Courtney
A1 Alonso-Gomez, Angel
A1 Fito, Montse
A1 Liang, Liming
A1 Corella, Dolores
A1 Gomez-Gracia, Enrique
A1 Estruch, Ramon
A1 Fiol, Miquel
A1 Lapetra, Jose
A1 Serra-Majem, Lluis
A1 Ros, Emilio
A1 Aros, Fernando
A1 Salas-Salvado, Jordi
A1 Hu, Frank B.
A1 Martinez-Gonzalez, Miguel A.
K1 tryptophan
K1 kynurenine
K1 heart failure
K1 atrial fibrillation
K1 metabolomics
K1 Mediterranean diet
K1 case-control
K1 PREDIMED
K1 Cardiovascular-disease
K1 Olive oil
K1 Inflammation
K1 Biomarkers
K1 Predictors
K1 Cancer
K1 Adults
AB Background: The tryptophan-kynurenine pathway is linked to inflammation. We hypothesize that metabolites implicated in this pathway may be associated with the risk of heart failure (HF) or atrial fibrillation (AF) in a population at high risk of cardiovascular disease.Objectives: We aimed to prospectively analyze the associations of kynurenine-related metabolites with the risk of HF and AF and to analyze a potential effect modification by the randomized interventions of the PREDIMED (Prevencion con Dieta MediterrAnea) trial with Mediterranean diet (MedDiet).Methods: Two case-control studies nested within the PREDIMED trial were designed. We selected 324 incident HF cases and 502 incident AF cases individually matched with
PB Oxford univ press
SN 0002-9165
YR 2021
FD 2021-07-22
LK https://hdl.handle.net/10668/26963
UL https://hdl.handle.net/10668/26963
LA en
DS RISalud
RD Apr 17, 2025