%0 Journal Article
%A Razquin, Cristina
%A Ruiz-Canela, Miguel
%A Toledo, Estefania
%A Hernandez-Alonso, Pablo
%A Clish, Clary B.
%A Guasch-Ferre, Marta
%A Li, Jun
%A Wittenbecher, Clemens
%A Dennis, Courtney
%A Alonso-Gomez, Angel
%A Fito, Montse
%A Liang, Liming
%A Corella, Dolores
%A Gomez-Gracia, Enrique
%A Estruch, Ramon
%A Fiol, Miquel
%A Lapetra, Jose
%A Serra-Majem, Lluis
%A Ros, Emilio
%A Aros, Fernando
%A Salas-Salvado, Jordi
%A Hu, Frank B.
%A Martinez-Gonzalez, Miguel A.
%T Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet
%D 2021
%@ 0002-9165
%U https://hdl.handle.net/10668/26963
%X Background: The tryptophan-kynurenine pathway is linked to inflammation. We hypothesize that metabolites implicated in this pathway may be associated with the risk of heart failure (HF) or atrial fibrillation (AF) in a population at high risk of cardiovascular disease.Objectives: We aimed to prospectively analyze the associations of kynurenine-related metabolites with the risk of HF and AF and to analyze a potential effect modification by the randomized interventions of the PREDIMED (Prevencion con Dieta MediterrAnea) trial with Mediterranean diet (MedDiet).Methods: Two case-control studies nested within the PREDIMED trial were designed. We selected 324 incident HF cases and 502 incident AF cases individually matched with
%K tryptophan
%K kynurenine
%K heart failure
%K atrial fibrillation
%K metabolomics
%K Mediterranean diet
%K case-control
%K PREDIMED
%K Cardiovascular-disease
%K Olive oil
%K Inflammation
%K Biomarkers
%K Predictors
%K Cancer
%K Adults
%~