Predictive Value of Immune Cell Functional Assay for Non-Cytomegalovirus Infection in Lung Transplant Recipients: A Multicenter Prospective Observational Study.
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2021-01-08
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Monforte, Víctor
Ussetti, Piedad
Castejón, Raquel
Sintes, Helena
Pérez, Virginia Luz
Laporta, Rosalía
Sole, Amparo
Cifrián, José Manuel
Marcos, Pedro J
Redel, Javier
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Abstract
Immune cell functional assay (ImmuKnow®) is a non-invasive method that measures the state of cellular immunity in immunosuppressed patients. We studied the prognostic value of the assay for predicting non-cytomegalovirus (CMV) infections in lung transplant recipients. A multicenter prospective observational study of 92 patients followed up from 6 to 12 months after transplantation was performed. Immune cell functional assay was carried out at 6, 8, 10, and 12 months. Twenty-three patients (25%) developed 29 non-CMV infections between 6 and 12 months post-transplant. At 6 months, the immune response was moderate (ATP 225-525ng/mL) in 14 (15.2%) patients and low (ATP Although ImmuKnow® does not seem useful to predict non-CMV infection, it could identify patients with a very low risk and help us define a target for an optimal immunosuppression.
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Immuknow, Immune cell assay, Immunknow, Immunosuppression, Infección, Infection, Inmunosupresión, Lung transplant, Test de inmunidad celular, Trasplante pulmonar