RT Journal Article
T1 Predictive Value of Immune Cell Functional Assay for Non-Cytomegalovirus Infection in Lung Transplant Recipients: A Multicenter Prospective Observational Study.
A1 Monforte, Víctor
A1 Ussetti, Piedad
A1 Castejón, Raquel
A1 Sintes, Helena
A1 Pérez, Virginia Luz
A1 Laporta, Rosalía
A1 Sole, Amparo
A1 Cifrián, José Manuel
A1 Marcos, Pedro J
A1 Redel, Javier
A1 Arcos, Ibai Los
A1 Berastegui, Cristina
A1 Alonso, Rodrigo
A1 Rosado, Silvia
A1 Escriva, Juan
A1 Iturbe, David
A1 Ovalle, Juan Pablo
A1 Vaquero, José Manuel
A1 López-Meseguer, Manuel
A1 Mendoza, Alberto
A1 Gómez-Ollés, Susana
K1 Immuknow
K1 Immune cell assay
K1 Immunknow
K1 Immunosuppression
K1 Infección
K1 Infection
K1 Inmunosupresión
K1 Lung transplant
K1 Test de inmunidad celular
K1 Trasplante pulmonar
AB Immune cell functional assay (ImmuKnow®) is a non-invasive method that measures the state of cellular immunity in immunosuppressed patients. We studied the prognostic value of the assay for predicting non-cytomegalovirus (CMV) infections in lung transplant recipients. A multicenter prospective observational study of 92 patients followed up from 6 to 12 months after transplantation was performed. Immune cell functional assay was carried out at 6, 8, 10, and 12 months. Twenty-three patients (25%) developed 29 non-CMV infections between 6 and 12 months post-transplant. At 6 months, the immune response was moderate (ATP 225-525ng/mL) in 14 (15.2%) patients and low (ATP Although ImmuKnow® does not seem useful to predict non-CMV infection, it could identify patients with a very low risk and help us define a target for an optimal immunosuppression.
YR 2021
FD 2021-01-08
LK https://hdl.handle.net/10668/25752
UL https://hdl.handle.net/10668/25752
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RD Apr 8, 2025