%0 Journal Article
%A Monforte, Víctor
%A Ussetti, Piedad
%A Castejón, Raquel
%A Sintes, Helena
%A Pérez, Virginia Luz
%A Laporta, Rosalía
%A Sole, Amparo
%A Cifrián, José Manuel
%A Marcos, Pedro J
%A Redel, Javier
%A Arcos, Ibai Los
%A Berastegui, Cristina
%A Alonso, Rodrigo
%A Rosado, Silvia
%A Escriva, Juan
%A Iturbe, David
%A Ovalle, Juan Pablo
%A Vaquero, José Manuel
%A López-Meseguer, Manuel
%A Mendoza, Alberto
%A Gómez-Ollés, Susana
%T Predictive Value of Immune Cell Functional Assay for Non-Cytomegalovirus Infection in Lung Transplant Recipients: A Multicenter Prospective Observational Study.
%D 2021
%U https://hdl.handle.net/10668/25752
%X Immune cell functional assay (ImmuKnow®) is a non-invasive method that measures the state of cellular immunity in immunosuppressed patients. We studied the prognostic value of the assay for predicting non-cytomegalovirus (CMV) infections in lung transplant recipients. A multicenter prospective observational study of 92 patients followed up from 6 to 12 months after transplantation was performed. Immune cell functional assay was carried out at 6, 8, 10, and 12 months. Twenty-three patients (25%) developed 29 non-CMV infections between 6 and 12 months post-transplant. At 6 months, the immune response was moderate (ATP 225-525ng/mL) in 14 (15.2%) patients and low (ATP Although ImmuKnow® does not seem useful to predict non-CMV infection, it could identify patients with a very low risk and help us define a target for an optimal immunosuppression.
%K Immuknow
%K Immune cell assay
%K Immunknow
%K Immunosuppression
%K Infección
%K Infection
%K Inmunosupresión
%K Lung transplant
%K Test de inmunidad celular
%K Trasplante pulmonar
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