Effects of arterial load variations on dynamic arterial elastance: an experimental study
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2017-06-01
Authors
Monge Garcia, M. I.
Guijo Gonzalez, P.
Gracia Romero, M.
Gil Cano, A.
Rhodes, A.
Grounds, R. M.
Cecconi, M.
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Elsevier sci ltd
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Abstract
Background. Dynamic arterial elastance (Ea(dyn)), the relationship between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a functional assessment of arterial load. The aim of this study was to evaluate the impact of arterial load changes during acute pharmacological changes, fluid administration, and haemorrhage on Eadyn.Methods. Eighteen anaesthetized, mechanically ventilated New Zealand rabbits were studied. Arterial load changes were induced by phenylephrine (n=9) or nitroprusside (n=9). Thereafter, animals received a fluid bolus (10 ml kg(-1)), followed by stepwise bleeding (blood loss: 15 ml kg(-1)). The influence of arterial load and cardiac variables on PPV, SVV, and Eadyn was analysed using a linear mixed-effects model analysis.Results. After phenylephrine infusion, mean (SD) Eadyn decreased from 0.89 (0.14) to 0.49 (0.12), P
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arterial pressure, cardiac output, pulse wave analysis, ultrasonography, Doppler, Pulse pressure, Stroke volume, Mechanical ventilation, Fluid responsiveness, Hemorrhage, Variables