RT Journal Article
T1 Effects of arterial load variations on dynamic arterial elastance: an experimental study
A1 Monge Garcia, M. I.
A1 Guijo Gonzalez, P.
A1 Gracia Romero, M.
A1 Gil Cano, A.
A1 Rhodes, A.
A1 Grounds, R. M.
A1 Cecconi, M.
K1 arterial pressure
K1 cardiac output
K1 pulse wave analysis
K1 ultrasonography
K1 Doppler
K1 Pulse pressure
K1 Stroke volume
K1 Mechanical ventilation
K1 Fluid responsiveness
K1 Hemorrhage
K1 Variables
AB Background. Dynamic arterial elastance (Ea(dyn)), the relationship between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a functional assessment of arterial load. The aim of this study was to evaluate the impact of arterial load changes during acute pharmacological changes, fluid administration, and haemorrhage on Eadyn.Methods. Eighteen anaesthetized, mechanically ventilated New Zealand rabbits were studied. Arterial load changes were induced by phenylephrine (n=9) or nitroprusside (n=9). Thereafter, animals received a fluid bolus (10 ml kg(-1)), followed by stepwise bleeding (blood loss: 15 ml kg(-1)). The influence of arterial load and cardiac variables on PPV, SVV, and Eadyn was analysed using a linear mixed-effects model analysis.Results. After phenylephrine infusion, mean (SD) Eadyn decreased from 0.89 (0.14) to 0.49 (0.12), P
PB Elsevier sci ltd
SN 0007-0912
YR 2017
FD 2017-06-01
LK https://hdl.handle.net/10668/25040
UL https://hdl.handle.net/10668/25040
LA en
DS RISalud
RD Apr 12, 2025